{"id":3854,"date":"2024-07-17T11:46:44","date_gmt":"2024-07-17T03:46:44","guid":{"rendered":"\/\/www.tradeda.com\/?p=3854"},"modified":"2024-07-17T11:47:27","modified_gmt":"2024-07-17T03:47:27","slug":"%e5%b8%b8%e7%94%a8%e8%af%95%e5%89%82-%e4%b8%89%e8%8b%af%e5%9f%ba%e8%86%a6","status":"publish","type":"post","link":"\/\/www.tradeda.com\/archives\/3854","title":{"rendered":"\u5e38\u7528\u8bd5\u5242—-\u4e09\u57fa\u81a6"},"content":{"rendered":"

\u5e38\u7528\u8bd5\u5242—-\u4e09\u57fa\u81a6<\/strong><\/a><\/p>\n

\u3010\u82f1\u6587\u540d\u79f0\u3011Triphenylphine<\/p>\n

\u3010\u5206\u5b50\u5f0f\u3011 C18H15P<\/p>\n

\u3010\u5206\u5b50\u91cf\u3011262.29<\/p>\n

\u3010CA\u767b\u5f55\u53f7\u3011[603-35-0]<\/p>\n

\u3010\u7ed3\u6784\u5f0f\u3011Ph3P<\/p>\n

\u3010\u7269\u7406\u6027\u8d28\u3011bp 337 oC\/1.0 mmHg\uff0cmp 79~81oC\uff0cd 1.18 g\/cm3\u3002\u4e3a\u767d\u8272\u6676\u4f53\uff0c\u6eb6\u4e8e\u5927\u591a\u6570\u6709\u673a\u6eb6\u5242\uff0c\u4e0d\u6eb6\u4e8e\u6c34\uff1b\u6613\u6eb6\u4e8e\u4e59\u9187\u3001\u3001\u6c2f\u4eff\uff1b\u6781\u6613\u6eb6\u4e8e\u3002<\/p>\n

\u3010\u5236\u5907\u548c\u5546\u54c1\u3011\u7531\u6b63\u5df1\u70f7\u3001\u7532\u9187\u6216\u800595%\u4e59\u9187\u7ed3\u6676\uff1b\u572865 oC\/1.0 mmHg \u4e0b\u7ecf\u8fc7CaSO4\u6216\u8005P2O5\u5e72\u71e5\uff0c\u53ef\u5f97\u5230\u7eaf\u51c0\u56fa\u4f53\u3002\u5927\u578b\u8de8\u56fd\u8bd5\u5242\u516c\u53f8\u5747\u6709\u9500\u552e\u3002<\/p>\n

\u3010\u6ce8\u610f\u4e8b\u9879\u3011\u8be5\u8bd5\u5242\u5728\u5267\u70c8\u66b4\u6652\u4e0b\u4f1a\u523a\u6fc0\u4eba\u4f53\uff0c\u5982\u679c\u957f\u65f6\u95f4\u63a5\u89e6\u6709\u795e\u7ecf\u6bd2\u6027\uff0c\u5c5e\u4e8e\u5371\u9669\u7269\u54c1\uff0c\u4e0d\u80fd\u4e0e\u5f3a\u6c27\u5316\u6027\u8bd5\u5242\u5171\u5b58\u3002\u82b3\u57fa\u81a6\u4e0e\u6c27\u7684\u53cd\u5e94\u6d3b\u6027\u6bd4\u82c4\u57fa\u548c\u70f7\u57fa\u81a6\u4f4e\u3002\u4f46\u662f\u7a7a\u6c14\u5bf9\u4e8e\u4e09\u57fa\u81a6\u7684\u6c27\u5316\u975e\u5e38\u660e\u663e\uff0c\u751f\u6210\u4e86\u4e09\u57fa\u81a6\u6c27\u5316\u7269\u3002\u4e09\u57fa\u81a6\u4e0d\u6613\u7740\u706b\u548c\u7206\u70b8\uff0c\u4f46\u662f\u5f53\u5b83\u52a0\u70ed\u5206\u89e3\u65f6\uff0c\u4f1a\u751f\u6210\u6709\u6bd2\u7684\u78f7\u5316\u6c22\u548cPOx\u70df\u96fe\u3002\u64cd\u4f5c\u65f6\u5e94\u5728\u901a\u98ce\u6a71\u4e2d\u8fdb\u884c\u3002<\/p>\n

\u4e09\u57fa\u81a6\u662f\u4e00\u79cd\u76f8\u5f53\u5e38\u7528\u7684\u8fd8\u539f\u5242\uff0c\u5728\u5927\u591a\u6570\u60c5\u51b5\u4e0b\uff0c\u53cd\u5e94\u90fd\u662f\u7531\u751f\u6210\u4e09\u57fa\u81a6\u6c27\u5316\u7269(\u4e00\u4e2a\u70ed\u529b\u5b66\u6709\u5229\u7684\u53cd\u5e94) \u9a71\u52a8\u7684\u3002\u53e6\u5916\uff0c\u4e09\u57fa\u81a6\u5e7f\u6cdb\u7528\u4f5c\u91d1\u5c5e\u50ac\u5316\u5242\u7684\u914d\u4f53\u3002<\/p>\n

\u8131\u6c27\u53cd\u5e94<\/p>\n

\u4e09\u57fa\u81a6\u5e7f\u6cdb\u5730\u5e94\u7528\u4e8e\u8fc7\u6c27\u5316\u6c22\u6216\u5185\u8fc7\u6c27\u5316\u7269\u7684\u8fd8\u539f\u4e2d\uff0c\u53cd\u5e94\u4e0e\u5e95\u7269\u6709<\/p>\n

\u5173\uff0c\u53ef\u751f\u6210\u9187\u3001\u7fb0\u57fa\u5316\u5408\u7269\u6216\u73af\u6c27\u5316\u7269\u3002\u8fd9\u7c7b\u53cd\u5e94\u7684\u4e3b\u8981\u9a71\u52a8\u529b\u662f\u4e09\u57fa\u81a6\u4e0e\u76f8\u5bf9\u8f83\u5f31\u7684O-O \u952e(188~209 kJ\/mol) \u80fd\u5f62\u6210\u8f83\u5f3a\u7684P=O\u952e\u3002\u4f8b\u5982\uff0c\u5229\u7528\u4e09\u57fa\u81a6\u53ef\u4ee5\u8fd8\u539f\u5206\u89e3\u81ed\u6c27\u5316\u7269\u3001\u9009\u62e9\u6027\u5236\u5907\u916e\u548c\u919b (\u5f0f1)[1]\u3002<\/p>\n

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\u4e0e\u53e0\u6c2e\u5316\u7269\u7684\u53cd\u5e94\u3010Staudinger\u8fd8\u539f\u3011<\/p>\n

\u4e09\u57fa\u81a6\u4e0e\u6709\u673a\u53e0\u6c2e\u5316\u5408\u7269\u53cd\u5e94\u751f\u6210\u4e9a\u6c28\u57fa\u81a6\u70f7 (\u5f0f2)[2]\u3002<\/p>\n

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\u4e9a\u6c28\u57fa\u81a6\u70f7\u662f\u4e00\u79cd\u8f83\u6d3b\u6cfc\u7684\u4eb2\u6838\u8bd5\u5242\uff0c\u6613\u4e0e\u4eb2\u7535\u8bd5\u5242\u53cd\u5e94\u3002\u5982\u4e0e\u919b\u548c\u916e\u53cd\u5e94\u751f\u6210\u4e9a\u80fa\u548c\u4e09\u57fa\u81a6\u6c27\u5316\u7269\u3002\u8fd9\u4e2a\u53cd\u5e94\u4e0eWittig\u53cd\u5e94\u76f8\u4f3c\uff0c\u79f0\u4f5caza-Wittig \u53cd\u5e94\uff0c\u8fd9\u4e2a\u53cd\u5e94\u7684\u9a71\u52a8\u529b\u4e5f\u662f\u7531\u4e8e\u4e09\u57fa\u6c27\u81a6\u7684\u751f\u6210 (\u5f0f3)[3]\u3002\u3010aza-Wittig\u53cd\u5e94\uff08\u6c2e\u6742Wittig\u53cd\u5e94\uff09\u3011<\/p>\n

<\/p>\n

\u4e0e\u6709\u673a\u786b\u5316\u7269\u7684\u53cd\u5e94\u3010Eschenmoser\u8131\u786b\u53cd\u5e94\u3011<\/p>\n

\u5ba4\u6e29\u4e0b\u4e09\u57fa\u81a6\u53ef\u4ee5\u4f7f\u73af\u786b\u5316\u5408\u7269\u8f6c\u5316\u4e3a\u70ef\u70c3 (\u5f0f4)[4]\u3002<\/p>\n

<\/p>\n

\u8131\u5364\u53cd\u5e94<\/p>\n

\u03b1-\u6eb4\u4ee3\u916e\u4e0e\u4e09\u57fa\u81a6\u53cd\u5e94\u751f\u6210\u916e (\u5f0f5)[5]\u3002<\/p>\n

<\/p>\n

\u4e0e\u6709\u673a\u73af\u6c27\u5316\u7269\u7684\u53cd\u5e94<\/p>\n

\u5728\u6c34\u548c\u4e19\u916e\u6eb6\u5242\u4e2d\u56de\u6d41\uff0c\u4e09\u57fa\u81a6\u53ef\u4ee5\u4f7f\u73af\u6c27\u5316\u5408\u7269\u5728\u53e0\u6c2e\u5316\u94a0\u53c2\u4e0e\u4e0b\u8f6c\u5316\u4e3a\u73af\u4e9a\u80fa (\u5f0f6)[6]\u3002<\/p>\n

<\/p>\n

\u53d6\u4ee3\u5421\u54af\u7684\u5236\u5907<\/p>\n

\u80fa\u3001\u544b\u5583\u4e8c\u916e\u4e0e\u4e09\u57fa\u81a6\u53cd\u5e94\u751f\u62101-\u57fa-2,5-\u5421\u54af\u4e8c\u916e (\u5f0f7)[7]\u3002<\/p>\n

<\/p>\n

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\u5b83\u4f5c\u4e3a\u914d\u4f53\u4e0e\u8bb8\u591a\u8fc7\u6e21\u91d1\u5c5e\u7ec4\u6210\u91d1\u5c5e\u50ac\u5316\u5242\uff0c\u5982Pd(PPh3)4 \u5c31\u662f\u4e00\u79cd\u91cd\u8981\u7684\u50ac\u5316\u5242[8]\uff0c\u5e38\u7528\u4e8e\u50ac\u5316\u5076\u8054\u53cd\u5e94\u7684\u8fdb\u884c\uff0c\u662f\u6784\u5efa\u78b3-\u78b3\u952e\u7684\u4e00\u79cd\u91cd\u8981\u65b9\u6cd5\uff0c\u5176\u7279\u70b9\u662f\u50ac\u5316\u6761\u4ef6\u6e29\u548c\u3002\u4f8b\u5982\uff0c\u5728Pd(PPh3)4\u548cAg2O\u7684\u5171\u540c\u4f5c\u7528\u4e0b\uff0c\u787c\u9178\u4e0e\u82b3\u9999\u5364\u4ee3\u70c3\u76f4\u63a5\u53cd\u5e94\u751f\u6210\u8054\u7c7b\u5316\u5408\u7269\uff0c\u8be5\u53cd\u5e94\u7684\u4ea7\u7387\u8fbe\u5230\u4e8690%(\u5f0f8)[9,10]\u3002\u9664\u4e86\u787c\u9178\u548c\u5364\u4ee3\u7269\u4ee5\u5916\uff0c\u9541\u8bd5\u5242[11]\u3001\u950c\u8bd5\u5242[12]\u3001\u9521\u8bd5\u5242[13]\u3001\u7845\u5316\u5408\u7269[14]\u7b49\u5747\u53ef\u4f5c\u4e3a\u5076\u8054\u53cd\u5e94\u7684\u5e95\u7269\u3002<\/p>\n

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\u5364\u4ee3\u7269\u7684\u5236\u5907\u3010Appel\u53cd\u5e94\u3011<\/p>\n

\u5229\u7528Appel\u53cd\u5e94\u5c06\u9187\u8f6c\u5316\u4e3a\u5364\u4ee3\u7269\u3002<\/p>\n

\u4e09\u57fa\u81a6\/\u54aa\u5511\/\u7898\u4f53\u7cfb\u7898\u4ee3\u53cd\u5e94<\/p>\n

\u5229\u7528\u4e09\u57fa\u81a6\u6eb4\u5316\u7269\u5236\u5907\u8102\u80aa\u6eb4\u4ee3\u7269<\/p>\n

\u9170\u80fa\u7684\u5236\u5907\u3010\u4e09\u57fa\u81a6\u7c7b\u7f29\u5408\u5242\u5236\u5907\u9170\u80fa\u3011<\/p>\n

Mitsunobu\u53cd\u5e94<\/p>\n

\u5229\u7528\u5076\u6c2e\u4e8c\u7fa7\u9178\u916f\uff08\u901a\u5e38\u4e3a\u5076\u6c2e\u4e8c\u7fa7\u9178\u4e8c\u4e59\u916f\uff0cDEAD\uff09\u548c\u4e09\u53d6\u4ee3\u81a6\u5316\u7269\uff08\u901a\u5e38\u4e3a\u4e09\u57fa\u81a6\uff09\uff0c\u4eb2\u6838\u8bd5\u5242\u548c\u9187\u8fdb\u884cSN2\u53cd\u5e94\u6784\u578b\u7ffb\u8f6c\u5f97\u5230\u6784\u578b\u76f8\u53cd\u7684\u53d6\u4ee3\u4ea7\u7269\u7684\u53cd\u5e94\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"

\u5e38\u7528\u8bd5\u5242—-\u4e09\u57fa\u81a6 \u3010\u82f1\u6587\u540d\u79f0\u3011Triphenylphine \u3010\u5206\u5b50\u5f0f\u3011 C18H15P \u3010\u5206\u5b50\u91cf\u3011262.29 \u3010CA\u767b\u5f55\u53f7\u3011… <\/p>\n","protected":false},"author":2,"featured_media":3855,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[3],"tags":[],"class_list":["post-3854","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news"],"_links":{"self":[{"href":"\/\/www.tradeda.com\/wp-json\/wp\/v2\/posts\/3854","targetHints":{"allow":["GET"]}}],"collection":[{"href":"\/\/www.tradeda.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"\/\/www.tradeda.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"\/\/www.tradeda.com\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"\/\/www.tradeda.com\/wp-json\/wp\/v2\/comments?post=3854"}],"version-history":[{"count":1,"href":"\/\/www.tradeda.com\/wp-json\/wp\/v2\/posts\/3854\/revisions"}],"predecessor-version":[{"id":3863,"href":"\/\/www.tradeda.com\/wp-json\/wp\/v2\/posts\/3854\/revisions\/3863"}],"wp:featuredmedia":[{"embeddable":true,"href":"\/\/www.tradeda.com\/wp-json\/wp\/v2\/media\/3855"}],"wp:attachment":[{"href":"\/\/www.tradeda.com\/wp-json\/wp\/v2\/media?parent=3854"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"\/\/www.tradeda.com\/wp-json\/wp\/v2\/categories?post=3854"},{"taxonomy":"post_tag","embeddable":true,"href":"\/\/www.tradeda.com\/wp-json\/wp\/v2\/tags?post=3854"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}